Spiffin’ coronavirus vaccine

football with mask by Capri23auto, Pixabay
(Capri23auto, Pixabay)

COVID-19 vaccines

The spiffin’ vaccine

Why is this important?

3D puzzle (Ulrike Mai, Pixabay)

A multivalent vaccine

References

  • HE, L., DE VAL, N., MORRIS, C.D., VORA, N., THINNES, T.C., KONG, L., AZADNIA, P., SOK, D., ZHOU, B., BURTON, D.R., WILSON, I.A., NEMAZEE, D., WARD, A.B. and ZHU, J., 2016. Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles. Nature communications, 7, pp. 12041–12041.
  • Khalili RA. 16/10/2020. MRDC. https://mrdc.amedd.army.mil/index.cfm/media/articles/2020/WRAIR_announces_COVID-19_vaccine_candidate
  • MA, X., ZOU, F., YU, F., LI, R., YUAN, Y., ZHANG, Y., ZHANG, X., DENG, J., CHEN, T., SONG, Z., QIAO, Y., ZHAN, Y., LIU, J., ZHANG, J., ZHANG, X., PENG, Z., LI, Y., LIN, Y., LIANG, L., WANG, G., CHEN, Y., CHEN, Q., PAN, T., HE, X. and ZHANG, H., 2020. Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses. Immunity, 53(6), pp. 1315–1330.e9.
  • POWELL, A.E., ZHANG, K., SANYAL, M., TANG, S., WEIDENBACHER, P.A., LI, S., PHAM, T.D., PAK, J.E., CHIU, W. and KIM, P.S., 2020. A single immunization with spike-functionalized ferritin vaccines elicits neutralizing antibody responses against SARS-CoV-2 in mice. bioRxiv, , pp. 2020.08.28.272518.
  • ZHANG, B., CHAO, C.W., TSYBOVSKY, Y., ABIONA, O.M., HUTCHINSON, G.B., MOLIVA, J.I., OLIA, A.S., PEGU, A., PHUNG, E., STEWART-JONES, G., VERARDI, R., WANG, L., WANG, S., WERNER, A., YANG, E.S., YAP, C., ZHOU, T., MASCOLA, J.R., SULLIVAN, N.J., GRAHAM, B.S., CORBETT, K.S. and KWONG, P.D., 2020. A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spike alone. Scientific Reports, 10(1), pp. 18149.

--

--

Former biomedical research scientist. Working on enterprise SSI. Love sharing knowledge. European citizen.

Get the Medium app

A button that says 'Download on the App Store', and if clicked it will lead you to the iOS App store
A button that says 'Get it on, Google Play', and if clicked it will lead you to the Google Play store
Chris Wirrig

Former biomedical research scientist. Working on enterprise SSI. Love sharing knowledge. European citizen.